Northwestern University Feinberg School of Medicine
Northwestern University
Clinical and Translational Sciences Institute

A CTSA partner accelerating discoveries toward human health

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Previous TL1 Fellows

Brian T. Burmeister, PhD

Senior Research Analyst at CMIC

Mentor:

Determining the Mechanism of Pediatric Doxorubicin-Induced Cardiotoxicity

Dr. Burmeister will be studying patient-specific responses to chemotherapy agents, specifically doxorubicin which is used to treat pediatric cancer patients. Doxorubicin is very effective in treating pediatric cancer, however one of the drug’s side effects, cardiotoxicity, limits it’s usefulness. As a result, Dr. Burmeister will be working to determine the molecular mechanisms that regulate doxorubicin-induced cardiotoxicity in order to identify new targets for drug discovery.

Michael Dominick DiVito, PhD

Mentor:

Differentiating Hepatocytes from iPSCs to Treat Pediatric Metabolic Liver Disease

Dr. DiVito will be studying ways to treat pediatric metabolic liver deficiencies using induced pluripotent (iPS) stem cells derived from liver cells. He plans to improve iPS cell differentiation protocols and to develop an infusion method for these cells with the overall goal of making both in vitro and living models of metabolic liver diseases that can be used to develop stem cell therapies and other treatments for these diseases. “I am excited at the potential of using stem cells with our lab’s bioreactor systems to develop disease models and cell therapies for pediatric metabolic diseases,” Dr. DiVito says. “With this award and the resources it offers, I feel I am in a great position to fulfill these goals. I am excited to see the output of this project after two years under the TL1 training program” Because the TL1 program promotes interdisciplinary mentorship, Dr. DiVito will be able to not only have the opportunity to enhance his engineering knowledge but also acquire new knowledge of hepatology, stem cell biology and other topics important to his research.

Daniel Giles Fort, MPH PhD

Director of Data Science/Biomedical Informatics Research at Ochsner Health System

Mentors:

Informatics Interventions to Accelerate Pediatric Clinical Trial Recruitment

Dan Fort, PhD, MPH, will be researching ways to use informatics in order to accelerate pediatric clinical trial recruitment. To do this, he will be looking at patterns in clinical trial recruitment success and failure as well as digging into historical cohort selection queries for insights into how they might be modified to increase the number of patients identified for recruitment. “This award is vital early career support, allowing me to build a solid body of investigatory, preliminary work for R-scale funding proposals as well as address important skill gaps in team and decision sciences,” said Dr. Fort.

Susan M. Slattery, MD

Mentor:

Process Vulnerabilities in Hospital Discharge after Neonatal Intensive Care Unit Stays

Dr. Slattery will be focusing her research on the timing of a safe transition home from the Neonatal Intensive Care Unit. Along with her mentors, she hopes to develop a valid, reliable predictive tool using data captured in the Electronic Health Record.

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